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ozi

Nkịtị

Melanoma nwere naanị 4% nke ọrịa kansa niile mana ọ bụ n'etiti egbu egbu na-egbu egbu. Dacarbazine bụ ọgwụ ahọrọ maka ọgwụgwọ nke melanoma na Brazil site na usoro ahụike ọha na eze tumadi n'ihi ọnụ ala ya. Otú ọ dị, ọ bụ onye na-ahụ maka ọdịdị dị ala ma na-ebute nzaghachi ọgwụgwọ na naanị 20% nke ikpe. Ọgwụ ndị ọzọ dị maka ọgwụgwọ melanoma dị oke ọnụ, sel ndị na-emepụta ọgwụ na-ebukarị iguzogide ọgwụ ndị a. Ọgụ megide melanoma chọrọ akwụkwọ ọhụụ, ọgwụ ndị akọwapụtara nke ọma bụ ndị dị irè na-egbu mkpụrụ ndụ tumo na-eguzogide ọgwụ. Nsonye Dibenzoylmethane (1,3-diphenylpropane-1,3-dione) bụ nkwa ndị ọrụ antitumor. N'ime ọmụmụ ihe a, anyị nyochara mmetụta cytotoxic nke 1,3-diphenyl-2-benzyl-1,3-propanedione (DPBP) na mkpụrụ ndụ B16F10 melanoma yana mmekọrịta ya na mkpụrụ ndụ DNA site na iji tweezers ngwa anya. DPBP gosipụtara nsonaazụ na-ekwe nkwa megide mkpụrụ ndụ tumo ma nwee ndepụta nhọrọ nke 41.94. Ọzọkwa, anyị gosipụtara ikike nke DPBP nwere mmekọrịta ozugbo na mkpụrụ ndụ DNA. Eziokwu ahụ bụ na DPBP nwere ike iji DNA na-emekọrịta ihe na vitro na-enye anyị ohere ịche na mmekọrịta dị otú ahụ nwekwara ike ime na vivo na, ya mere, na DPBP nwere ike ịbụ ihe ọzọ iji gwọọ ndị ọrịa nwere melanomas na-eguzogide ọgwụ. Nchọpụta ndị a nwere ike iduzi mmepe nke ọgwụ ọhụụ na nke dị irè karị.

Eserese eserese

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Mpempe nke ọnụọgụ ọnwụ cell nwetara maka DPBP compound megide melan-A na B16F10 akara dị iche iche. Ntugharị nhọrọ (SI = IC50 melan-A / IC50 B16F10) bụ 41.94.                    

Nke Elsevier BV bipụtara

Nkịtị

Dibenzoylmethane (DBM) bụ obere ihe mejupụtara nke licorice na β-diketone analog nke curcumin. Inye ụmụ oke Sencar nri na 1% DBM na nri mgbe oge mbido na mbido oge gbochiri 7,12-dimethylbenz [a] anthracene (DMBA) nke nwere oke mammary na ọnya mammary site na 97%. N'ịga n'ihu na ọmụmụ ihe ọmụmụ iji kọwaa usoro omume nke ihe mgbochi nke DBM, inye 1% DBM na nri AIN-76A ka ụmụ oke ụmụ Sencar na-eto eto maka izu 4-5 belata mgbatị mmiri nke akpanwa site na 43%, gbochie ọnụ ọgụgụ mmụba ahụ. nke mkpụrụ ndụ epithelial mammary gland site na 53%, epithelium nke uterine site na 23%, na stroma uterine site na 77%, mgbe e gburu ụmụ oke n'oge nke mbụ estrus phase nke okirikiri. Na mgbakwunye, inye 1% DBM nri na ụmụ oke Sencar na izu 2 tupu, n'oge na 1 izu mgbe ọgwụgwọ DMBA gasịrị (intubation nke 1 mg DMBA kwa oke otu ugboro n'izu maka izu 5) gbochiri ngụkọta nke DMBA-DNA niile na mammary glands site na 72% site na iji nnwale post-32P. Ya mere, inye nri ụmụ nwanyị Sencar nri 1% DBM gbochiri nguzobe DMBA – DNA na mammary glands ma belata mmụba ụba nke mammary gland na vivo. Nsonaazụ ndị a nwere ike ịkọwa ọrụ mgbochi siri ike nke DBM na-eri nri na mammary carcinogenesis na ụmụ oke.


Post oge: Ọgọstụ-12-2020